Take exit (N 22) towards Orange Sud, at first round about, take exit direction Sarrians
At Sarrians, take turn left onto the D21 towards Beaume de Venise, until arriving at St Hippolyte.
Take exit (N 21) towards Orange Centre and do a U-turn after the first round about after the toll and head back onto the motorway towards Marseille.
Take exit (N 22) towards Orange Sud, and follow the same instructions as when coming from the North.
Take exit (N23) towards Carpentras/Vedene/Sorgues
Follow the express way (D942) for 15 Kms, around Carpentra keeping on the D942
On the northern ring road, at the second round about, take the RD938 towards Serres/Malaucene/Mont Ventoux/Vaison-La-Romaine for 6.7 kms
Then turn left onto the RD21 for 650 m.
You are almost there !